AnaLight BioFlex

World's First Automated Biomolecular Structure-Function Assay Platform

The AnaLight BioFlex brings DPI's unique biomolecular structure-function measurements into discovery and development facilities with a need for automated sample throughput in a range of biophysical applications.

The AnaLight BioFlex is a "molecular microscope" whose quantitative structural measurements can be compared directly with complementary techniques such as such as X-ray crystallography, circular dichroism and NMR spectroscopy, whilst also being capable of affinity and kinetic mass measurements at higher sensitivity than first-generation optical or acoustic biosensor technologies.

Key Features:

	Automated sample loading for unattended throughput
	Autosampler provides precision sample loading from 50-vial, 96-well and 384-well sample formats
	Twin flow cells give simultaneous, parallel sample analysis for control and comparison
	Software provides integrated sample handling and data processing throughout
	Simultaneous measurement on three channels gives total confidence in data integrity
	Full intuitive method scripting for unattended operation with manual intervention feature during runs
	Wide dynamic range extends solvent and buffer handling capabilities
	Accurate temperature control and rapid temperature stabilisation
	Flexible range of analytical surfaces and reagents available to suit all applications
	Simple upgrade path from manual AnaLight Bio200

Key functions:

	Instantaneous, quantitative measurement of biomolecular dimensions, fold density (RI) and mass on two parallel measurement surfaces with automated throughput
	Software gives option of automated reference channel subtraction when running parallel control experiments
	AnaLight software provides comprehensive analysis of mass changes, affinity, interaction kinetics and structural behaviour in quantitative units
	Measures conformational changes in biomolecules as small as 0.1 Ångstrom as they happen, with or without any mass change
	Measures mass changes as low as 0.1 picogram/mm2 in real time, giving class-leading kinetic performance
	Provides a unique information set on the behaviour and interactions of biomolecules with industry-leading resolution
	Automated AnaChip and solvent calibration protocols ensure ultimate measurement accuracy

Consumables

		AnaChips for BioPhysics Farfield offers a range of AnaChips suitable for biophysical applications. The most suitable AnaChip surface for any biomolecular immobilization should be assessed according to the properties of the molecule to be immobilized and the objectives behind the measurements being taken on the AnaLight.